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Back to Cancer Genomics

What is gene expression?

Proteins communicate Signals

Proteins communicate Signals

    In a cell, a gene is expressed when information is taken from the gene and used to create a protein. DNA transcription produces RNA, then RNA translation makes proteins. A cell expresses only a selection of the genes it contains at any one time. By controlling which genes are expressed, the cell controls its size, shape, and functions. 

Proteins communicate Signals

Proteins communicate Signals

Proteins communicate Signals

 Proteins are the "workhorse" molecules, taking part in every structure and activity of life. To perform their functions, proteins communicate in a network, comparable to how humans behave in social media networks. In cancer, there are changes in proteins that lead to miscommunications.

Differences in gene expression lead to differences in Cells

Differences in gene expression lead to differences in Cells

Differences in gene expression lead to differences in Cells

  Cells from healthy breast tissue and tumors have different characteristics . Once a genome has been sequenced, we know what potential a cell has—what characteristics and functions it might exhibit—based on the genes it contains. However, sequencing the genome does not tell us which genes a cell is expressing. Knowing which genes are expressed—the cell’s gene expression profile—gives us clues about the cell’s functions. 

What is gene expression profiling?

Differences in gene expression lead to differences in Cells

Differences in gene expression lead to differences in Cells

 In gene expression profiling experiments, measuring mRNA levels shows which genes have been transcribed to mRNA and, thus, have the potential to be translated to protein.  Changes in protein function can be detected indirectly by measuring the levels of the mRNA molecules that code for the proteins.  

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